Healthy elderly subjects (65-81 years) showed a statistically significant increase in AUC of sildenafil and the N-desmethyl metabolite of about 90% compared to young healthy subjects (18-45 years). tadalafil There were evidence of dilatations of the central veins, which contained lysed red blood cells and cyto-architectural distortions of the hepatocytes and centrilobular haemorrhagic necrosis..

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